| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2124 | |
| Phytochemical name or plant extracts | Polyphylloside A | |
| PMID | 32244126 | |
| Literature evidence | Among these, the known saponins 7 and 10 exhibited significant cytotoxic effects on HeLa cells with IC50 values of 4.16 and 4.45 μM, respectively. | |
| IUPAC name | (25R)-6α-hydroxy-spirost-4-ene-3β-yl α-L-rhamnopyranosyl- (1 → 4)-[α-L-rhamnopyranosyl-(1 → 2)]-β-D-glucopyranoside | |
| Phytochemicals’ class or type of plant extracts | Spirostanol saponin | |
| Source of phytochemicals or plant Extracts | Paris polyohylla | |
| Geographical availability | Assam, Bangladesh, China North-Central, China South-Central, East Himalaya, Myanmar, Nepal, Qinghai, Tibet, West Himalaya | |
| Plant parts | Stem and leaves | |
| Other cancers | Breast cancer, Lung cancer, Cervical cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 26.31 ± 0.49 μM against MCF-7 18.36 ± 0.84 μM against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MDA-MB-231, A549, HeLa, HCT-116 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:539722-1 | |
| Safety | NA |