| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-552 | |
| Phytochemical name or plant extracts | Polyphyllin VI | |
| PMID | 30817902 | |
| Literature evidence | The current work thus demonstrates for the first time that targeted regulation of Rell2 by miR-18a is in part implicated in the anti-metastatic effect of PP-VI in breast cancer cells, providing novel pharmacological insights into the anti-cancer effect of PP-VI. | |
| IUPAC name | (2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(1R,2S,4S,5'R,6R,7S,8S,9S,12S,13R,16S)-8-hydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Saponin | |
| Source of phytochemicals or plant Extracts | Paris polyphylla Sm | |
| Geographical availability | Assam, Bangladesh, China North-Central, China South-Central, East Himalaya, Myanmar, Nepal, Qinghai, Tibet, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Rell2, miR-18a | |
| Gene or Protein evidence | PP-VI treatment resulted in increased expression of Rell2 and decreased level of miR-18a in 4T1 and MDA-MB-231 cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The current work thus demonstrates for the first time that targeted regulation of Rell2 by miR-18a is in part implicated in the anti-metastatic effect of PP-VI in breast cancer cells, providing novel pharmacological insights into the anti-cancer effect of PP-VI. | |
| Cell line/ mice model | Mouse mammary carcinoma 4T1, MDA-MB-231 | |
| Additional information | PP-VI treatment also attenuated miR-18a mimic or Rell2 siRNA-augmented migration of MDA-MB-231 cells. | |
| PubChem ID | 10417550 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:539722-1 | |
| Safety | NA |