| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1448 | |
| Phytochemical name or plant extracts | Polyphyllin V | |
| PMID | 32244126 | |
| Literature evidence | Among these, the known saponins 7 and 10 exhibited significant cytotoxic effects on HeLa cells with IC50 values of 4.16 and 4.45 μM, respectively. | |
| IUPAC name | (2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Saponin | |
| Source of phytochemicals or plant Extracts | Paris polyohylla var chinensis | |
| Geographical availability | Assam, Bangladesh, China North-Central, China South-Central, East Himalaya, Myanmar, Nepal, Qinghai, Tibet, West Himalaya | |
| Plant parts | Leaves and stem | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 5.65 ± 0.41 µM against MCF-7 2.57 ± 0.02 µM against MDA-MB-231 | |
| Potency | Flow cytometric analysis indicated that 7 could induce MDA-MB-231 cell death in a concentration-dependent manner. Saponin 7 was proved to affect the cell cycle distribution and induced G2/M phase arrest in MDA-MB-231 cells. Compound 7 is Polyphyllin V | |
| Cell line/ mice model | MDA-MB-231, HeLa | |
| Additional information | Induces G2/M phase arrest in MDA-MB-231 cells | |
| PubChem ID | 101377612 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:539722-1 | |
| Safety | NA |