| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-553 | |
| Phytochemical name or plant extracts | Polyphyllin D | |
| PMID | 34481873 | |
| Literature evidence | Moreover, PD treatment could induce autophagy by activation of JNK1/Bcl-2 pathway. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Glycoside | |
| Source of phytochemicals or plant Extracts | Paris polyphylla | |
| Geographical availability | Assam, Bangladesh, China North-Central, China South-Central, East Himalaya, Myanmar, Nepal, Qinghai, Tibet, West Himalaya | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | Beclin-1, Caspase 3 | |
| Gene or Protein evidence | Consistently, caspase 3 activity also elevated after PD treatment, indicating that PD induced apoptosis through the activation of caspase proteins. Beclin 1 is indispensable for PD induced autophagy. | |
| Target pathways | JNK1/Bcl-2 pathway | |
| IC50 | NA | |
| Potency | PD could induce caspase-dependent apoptosis and cyto-protectvie autophagy by activation of JNK1/Bcl-2 pathway in breast cancer cells. | |
| Cell line/ mice model | NA | |
| Additional information | Combination with an autophagy inhibitor significantly enhance cytotoxic effect of PD and this combination may be a promising candidate for breast cancer therapy. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:539722-1 | |
| Safety | NA |