| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1355 | |
| Phytochemical name or plant extracts | Polyphenols of Artichoke | |
| PMID | 26180585 | |
| Literature evidence | High doses of polyphenolic extracts (AEs) induce apoptosis and decrease the invasive potential of the human breast cancer cell line, MDA-MB231. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Polyphenolic extract | |
| Source of phytochemicals or plant Extracts | Cynara scolymus | |
| Geographical availability | Albania, Algeria, Baleares, Canary Is., France, Italy, Libya, Madeira, Morocco, Portugal, Sicilia, Spain, Tunisia, Yugoslavia | |
| Plant parts | Edible parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | p16(INK4a), p21 (Cip1/Waf1) | |
| Gene or Protein evidence | AEs exposure induces a significant increase of senescence-associated β-galactosidase (SA-β-gal) staining and upregulation of tumour suppressor genes, p16(INK4a) and p21(Cip1/Waf1) in MDA-MB231 cells. | |
| Target pathways | p21Cip1/Waf1 and p16INK4a pathways. | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Accordingly, we show that AEs-induced growth arrest is associated with increased ROS production, suggesting that AEs may induce senescence via an oxidative-mediated damage in breast cancer cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77180272-1 | |
| Safety | NA |