| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-716 | |
| Phytochemical name or plant extracts | Polyphenolics from mango | |
| PMID | 27951515 | |
| Literature evidence | These results suggest that mango polyphenols and their major microbial metabolite, pyrogallol, inhibit proliferation of breast cancer cells through ROS-dependent up-regulation of AMPK and down-regulation of the AKT/mTOR pathway. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Polyphenol | |
| Source of phytochemicals or plant Extracts | Mangifera indica | |
| Geographical availability | Assam, Belize, China South-Central, East Himalaya, Myanmar, Thailand | |
| Plant parts | Pulp | |
| Other cancers | Breast cancer | |
| Target gene or protein | IR, IRS1, IGF-1R, mTOR | |
| Gene or Protein evidence | There was a significant reduction of phosphorylated protein levels of IR, IRS1, IGF-1R, and mTOR by mango, while pyrogallol significantly reduced the phosphorylation levels of IR, IRS1, IGF-1R, p70S6K, and ERK. | |
| Target pathways | AKT/mTOR pathway | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | Female athymic BALB/c nude mice | |
| Additional information | These results suggest that mango polyphenols and their major microbial metabolite, pyrogallol, inhibit proliferation of breast cancer cells through ROS-dependent up-regulation of AMPK and down-regulation of the AKT/mTOR pathway. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:69913-1 | |
| Safety | NA |