| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-629 | |
| Phytochemical name or plant extracts | Polymethoxyflavones | |
| PMID | 17979096 | |
| Literature evidence | Apoptosis-inducing activity of hydroxylated polymethoxyflavones and polymethoxyflavones from orange peel in human breast cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Citrus sinensis | |
| Geographical availability | Albania, Algeria, Angola, Argentina Northeast, Argentina Northwest, Assam, Bahamas, Bangladesh, Belize, Benin, Bermuda, Borneo, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Cambodia, Canary Is., Caroline Is., Cayman Is., Central American Pac, China North-Central, China South-Central, China Southeast, Cook Is., Costa Rica, Cuba, Dominican Republic, East Himalaya, Ecuador, Egypt, El Salvador, Ethiopia, Florida, Gambia, Guinea-Bissau, Gulf of Guinea Is., Haiti, Honduras, India, Iraq, Italy, Jamaica, Japan, Korea, Laos, Leeward Is., Libya, Line Is., Louisiana, Madeira, Marianas, Mauritius, Mexico Southeast, Morocco, Myanmar, Nansei-shoto, Nepal, New Caledonia, Pakistan, Panamá, Paraguay, Peru, Philippines, Portugal, Puerto Rico, Rodrigues, Réunion, Santa Cruz Is., Socotra, Solomon Is., Somalia, Spain, Sri Lanka, Tadzhikistan, Taiwan, Tibet, Trinidad-Tobago, Tuamotu, Tunisia, Vanuatu, Venezuela, Vietnam, Wallis-Futuna Is., West Himalaya | |
| Plant parts | Peels | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our results strongly imply that bioactive PMFs from orange peel exert proapoptotic activity in human breast cancer cells, which depends on their ability to induce an increase in intracellular Ca(2+ )and thus, activate Ca(2+)-dependent apoptotic proteases. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Here, we report that the fraction of orange peel extract containing a mixture of non-hydroxylated PMFs (75.1%) and hydroxylated PMFs (5.44%) and the fraction containing only hydroxylated PMFs (97.2%) induce apoptosis in those cells as well. | |
| PubChem ID | NA | |
| Additional PMIDs | 17979096 17046027 28177754 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:59600-2 | |
| Safety | NA |