Phytochemical Name : Polygonum avicular extract

Properties Information
PhytoCAT-ID PhytoCAT-708
Phytochemical name or plant extracts Polygonum avicular extract
PMID 22615677
Literature evidence RT-PCR results showed up-regulation of P53 and down-regulation of Bcl-2 proteins which implied the ability of Polygonum avicular to induce apoptosis in MCF-7 cells and confirmed its anticancer property.
IUPAC name NA
Phytochemicals’ class or type of plant extracts Methanolic extract
Source of phytochemicals or plant Extracts Polygonum avicular
Geographical availability Afghanistan, Alabama, Alaska, Albania, Alberta, Algeria, Altay, Amur, Arizona, Arkansas, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, British Columbia, Bulgaria, Buryatiya, California, Canary Is., Central European Rus, China North-Central, China South-Central, China Southeast, Chita, Colorado, Connecticut, Corse, Costa Rica, Cyprus, Czechoslovakia, Delaware, Denmark, District of Columbia, East Aegean Is., East European Russia, East Himalaya, Egypt, Eritrea, Ethiopia, Finland, Florida, France, Føroyar, Georgia, Germany, Great Britain, Greece, Hainan, Hungary, Iceland, Idaho, Illinois, Indiana, Inner Mongolia, Iowa, Iran, Iraq, Ireland, Irkutsk, Italy, Japan, Kamchatka, Kansas, Kazakhstan, Kentucky, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Kriti, Krym, Kuril Is., Labrador, Lebanon-Syria, Libya, Louisiana, Madeira, Magadan, Maine, Manchuria, Manitoba, Maryland, Michigan, Minnesota, Mississippi, Missouri, Montana, Morocco, Myanmar, Nansei-shoto, Nebraska, Nepal, Netherlands, Nevada, New Brunswick, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Caucasus, North Dakota, North European Russi, Northwest European R, Northwest Territorie, Norway, Nova Scotia, Ohio, Oklahoma, Ontario, Oregon, Pakistan, Palestine, Pennsylvania, Poland, Portugal, Primorye, Qinghai, Québec, Rhode I., Romania, Sakhalin, Sardegna, Saskatchewan, Saudi Arabia, Sicilia, South Carolina, South Dakota, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Taiwan, Tennessee, Texas, Tibet, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Utah, Uzbekistan, Vermont, Virginia, Washington, West Himalaya, West Siberia, West Virginia, Wisconsin, Wyoming, Xinjiang, Yakutskiya, Yemen, Yugoslavia, Yukon
Plant parts Aerial parts
Other cancers Breast cancer
Target gene or protein p53 , Bcl-2
Gene or Protein evidence RT-PCR results showed up-regulation of P53 and down-regulation of Bcl-2 proteins which implied the ability of Polygonum avicular to induce apoptosis in MCF-7 cells and confirmed its anticancer property.
Target pathways NA
IC50 NA
Potency Results showed that Polygonum avicular induced cytotoxicity in MCF-7 cell line at concentrations higher than 300 ng/µl and this was confirmed by the highest rate of cell death as measured by Trypan Blue and MTT assays.
Cell line/ mice model MCF-7
Additional information  Results showed high cytotoxicity of the extract at the concentrations of 300 and 350 ng/µl after 24 hrs compared to the controls Ninety nine percent cell death occurred at the concentration of 400 ng/µl after 24 hrs
PubChem ID NA
Additional PMIDs NA
Additional sources of information https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:695422-1
Safety NA