| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1163 | |
| Phytochemical name or plant extracts | Polygonatum odoratum extract | |
| PMID | 27698772 | |
| Literature evidence | In conclusion, these results showed that the P. odoratum extract inhibited the proliferation and induced apoptosis of breast cancer MDA-MB-231 cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic and Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Polygonatum odoratum | |
| Geographical availability | Albania, Altay, Amur, Austria, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Central European Rus, China North-Central, China Southeast, Chita, Corse, Czechoslovakia, Denmark, East European Russia, Finland, France, Germany, Great Britain, Greece, Hungary, Inner Mongolia, Irkutsk, Italy, Japan, Kamchatka, Kazakhstan, Khabarovsk, Korea, Krasnoyarsk, Krym, Kuril Is., Manchuria, Mongolia, Morocco, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Poland, Portugal, Primorye, Qinghai, Romania, Sakhalin, Sicilia, South European Russi, Spain, Sweden, Switzerland, Tuva, Ukraine, West Siberia, Yakutskiya, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Bax | |
| Gene or Protein evidence | The extract also lowered the ΔΨm of MDA-MB-231 cells, upregulated the expression of Bax and inhibited the expression of Bcl-2. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In conclusion, these results showed that the P. odoratum extract inhibited the proliferation and induced apoptosis of breast cancer MDA-MB-231 cells. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | The results of the MTT assay showed that the proliferation and colony formation of MDA-MB-231 cells were inhibited following treatment with the extract. Furthermore, the PI/Annexin-V staining showed that the apoptosis of MDA-MB-231 cells was enhanced by the extract, in a concentration-dependent manner. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:540195-1 | |
| Safety | NA |