| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2085 | |
| Phytochemical name or plant extracts | Polydatin (PD) | |
| PMID | 28467448 | |
| Literature evidence | Results suggest that PD is a potential therapeutic natural compound. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Stilbene | |
| Source of phytochemicals or plant Extracts | Polygonum cuspidatum | |
| Geographical availability | Argentina Northeast, Argentina Northwest, Belize, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Chile Central, Colombia, Costa Rica, Cuba, Desventurados Is., Dominican Republic, Easter Is., Ecuador, French Guiana, Galápagos, Guatemala, Guyana, Haiti, Honduras, Jamaica, Leeward Is., Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Paraguay, Peru, Puerto Rico, Suriname, Trinidad-Tobago, Uruguay, Venezuela | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Creb, Cyclin D1 | |
| Gene or Protein evidence | Cell cycle analysis demonstrated that PD induced S-phase cell cycle arrest. Human phosphor-kinase arrays showed that the phosphorylation level of cAMP response element-bingding proteins(Creb) was down-regulated, and the results were further confirmed by Western blot analysis. PD down-regulates cyclin D1 expression in breast cancer cell lines | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | Results showed that PD effectively inhibited the growth of MDA-MB-231 and MCF-7 breast cancer cell lines. Cell cycle analysis demonstrated that PD induced S-phase cell cycle arrest. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60454800-2 | |
| Safety | NA |