| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1162 | |
| Phytochemical name or plant extracts | Podophyllum hexandrum extract | |
| PMID | 21845801 | |
| Literature evidence | Increase in the catalase activity appears to be a response to H2O2 accumulation. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Podophyllum hexandrum | |
| Geographical availability | Afghanistan, China North-Central, China South-Central, East Himalaya, Nepal, Pakistan, Qinghai, Tibet, West Himalaya | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer, Lung cancer, Prostate cancer, Colon cancer, Neuroblastoma and CNS | |
| Target gene or protein | Catalase, Superoxide dismutase, Glutathione peroxidase | |
| Gene or Protein evidence | The decrease in the activity of catalase and increase in the activity of superoxide dismutase and glutathione peroxidase in different organs of the rats receiving Podophyllum hexandrum extract and alpha-tocopherol indicates the protective effect of the plant in combating oxidative stress undergone by the rats. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These findings 1 - showed that Podophyllum hexandrum extract may ameliorate H2O2 induced oxidative stress by decreasing lipid peroxidation via alteration of the antioxidant defense system of the rats. 2 - these data also showed the anticancer activity of the plant extracts on different human cancer cell lines. | |
| Cell line/ mice model | MCF-7, A-549, PC-3, Colo-25, IMR-32, SF-295, MDA-MB-231 | |
| Additional information | Methanol and 70% ethanolic extracts of the rhizome of Podophyllum hexandrum showed highest cytotoxic effect on MCF-7 (Breast) and Colo-25 (Colon) cell line, as determined with sulforhodamine-B (SRB) assay. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:327192-2 | |
| Safety | NA |