| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1725 | |
| Phytochemical name or plant extracts | Pleurotus ostreatus extracts | |
| PMID | 19020765 | |
| Literature evidence | Here, we identified as the most potent, P. ostreatus (oyster mushroom) which suppressed proliferation of breast cancer (MCF-7, MDA-MB-231) and colon cancer (HT-29, HCT-116) cells, without affecting proliferation of epithelial mammary MCF-10A and normal colon FHC cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Pleurotus ostreatus | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | These results indicate bioactive 6-linked glucans present in P. ostreatus extracts activate NK-cell cytotoxicity via regulation of activation and induction of IFNγ and NO..P. ostreatus suppresses the proliferation of breast and colon cancer cells via p53-dependent as well as p53-independent pathway. | |
| IC50 | NA | |
| Potency | In conclusion, our results indicated that the edible oyster mushroom has potential therapeutic/preventive effects on breast and colon cancer. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HT-29, HCT-116 | |
| Additional information | our data suggest that P. ostreatus significantly inhibits proliferation of human breast cancer cells MCF-7 and colon cancer cells HT-29 by G0/G1 cell cycle arrest. Therefore, P. ostreatus induces cell cycle arrest of MCF-7 by the up-regulation of the expression of p53 and p21, whereas cell cycle arrest of HT-29 is induced by the up-regulation of the expression of p21 | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |