| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-88 | |
| Phytochemical name or plant extracts | Plectranthus amboinicus extract | |
| PMID | 33899147 | |
| Literature evidence | Cancer is a universal health issue, and many anticancer therapeutic drugs have been isolated from natural products. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Hexane extract | |
| Source of phytochemicals or plant Extracts | Plectranthus amboinicus | |
| Geographical availability | Angola, Burundi, India, Kenya, KwaZulu-Natal, Mozambique, Swaziland, Tanzania, Yemen | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin D1, Caspase 9, p53 | |
| Gene or Protein evidence | The Plectranthus amboinicus, (Lour.) Spreng. Leaves Ethanolic Extract Nanoparticles could be an effective anticancer by improving its downregulation on cyclinD1, upregulation caspase-9 and p53. | |
| Target pathways | NA | |
| IC50 | 39.26 μg/mL against MDA-MB-231 89.05 μg/mL against MCF-7 | |
| Potency | PALH extract can be considered nontoxic as it does not cause any adverse changes and so can be proposed as a potential breast anticancer agent. | |
| Cell line/ mice model | T47D, MDA-MB-231, MCF-7 | |
| Additional information | Treatment with Plectranthus amboinicus (Lour.) Spreng. ethanolic extract nanoparticles (PAEEN) inhibited the proliferation of T47D cell lines after 48 hours and 72 hours of incubation at concentrations of 22.3 μg/mL, 44.6 μg/mL, and 89.2 μg/mL. | |
| PubChem ID | NA | |
| Additional PMIDs | 30912412 33899147 32127976 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:168806-3 | |
| Safety | NA |