| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1160 | |
| Phytochemical name or plant extracts | Plantago major extract | |
| PMID | 28839362 | |
| Literature evidence | SUMMARY: Amongst the parts of Plantago major, seeds exhibited the greatest antiproliferative activity against MCF-7, MDA-MB-231, HeLaS3, A549, and KB cell lines as well as the highest inhibition on TNF-α, IL-1β, IL-6, and IFN-γ productionThe roots, which were commonly discarded, exhibited comparable antiproliferative and cytokines inhibition activities to those of leaves and petiolesUrsolic acid, a chemical compound of Plantago major, exhibited stronger activities than oleanolic acid and aucubinThe seeds are being proposed as the main source for further development of anticancer and anti inflammatory products, whereas the roots could be included in the preparation of Plantago major derived products with respect to anti inflammatory. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanol and Aqueous extract | |
| Source of phytochemicals or plant Extracts | Plantago major | |
| Geographical availability | Albania, Altay, Amur, Austria, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Central European Rus, Chita, Czechoslovakia, Denmark, East European Russia, Finland, France, Germany, Great Britain, Greece, Hungary, Iran, Iraq, Irkutsk, Italy, Kazakhstan, Khabarovsk, Kirgizstan, Krasnoyarsk, Krym, Kuril Is., Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Poland, Primorye, Romania, Sakhalin, South European Russi, Spain, Sweden, Switzerland, Turkey, Tuva, Ukraine, West Siberia, Yakutskiya, Yugoslavia | |
| Plant parts | Root and seeds | |
| Other cancers | Breast cancer, Cervical cancer, Lung cancer, Nasopharynx cancer | |
| Target gene or protein | TNF-α, IL-1β, IL-6, IFN-γ | |
| Gene or Protein evidence | The methanol extracts of seeds also demonstrated the highest inhibition of TNF-α, IL-1β, IL-6, and IFN-γ production. | |
| Target pathways | NA | |
| IC50 | Among the extracts tested, methanol extracts of P. major seeds exhibited the most potent antiproliferative activity against five cancer cell lines used with IC50 values between 153.38 and 247.41 μg/ml. | |
| Potency | The seeds are being proposed as the main source for further development of anticancer and anti inflammatory products, whereas the roots could be included in the preparation of Plantago major derived products with respect to anti inflammatory. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HeLaS3, A549, and KB | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:685411-1 | |
| Safety | NA |