| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1158 | |
| Phytochemical name or plant extracts | Pithecellobium dulce extract | |
| PMID | 26996293 | |
| Literature evidence | The induction of apoptosis in the breast cancer cells after treatment was confirmed by significant percentage (24.7%), of early apoptotic cells (AnnexinV (+) Propidium Iodide(_) ) in treated cells as compared to control cells (3.5%). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Pithecellobium dulce | |
| Geographical availability | Belize, Colombia, El Salvador, Guatemala, Guyana, Honduras, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Peru, Venezuela | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, p21, p53 , TNF, fasBcl-2, NF-κB, CDK | |
| Gene or Protein evidence | The induction of apoptosis in the breast cancer cells after treatment was confirmed by significant percentage (24.7%), of early apoptotic cells (AnnexinV (+) Propidium Iodide(_) ) in treated cells as compared to control cells (3.5%). We observed a significant upregulation in the mRNA expression of various pro-apoptotic gene such as Bax (21.1 folds), p21(14.4 folds), p53 (11.7 folds), TNF (10.2 folds) and fas (6.3 folds) after treatment as compared to untreated cells. On the other hand, the relative mRNA expression of anti-apoptotic genes such as Bcl-2, NF-KB and Cdk was reduced. | |
| Target pathways | NA | |
| IC50 | 300 mg/mL againstf MCF-7 cells for 48h | |
| Potency | The selective upregulation of pro-apoptotic gene and down regulation of specific anti-apoptotic genes could be the inducing factor for apoptotic cell death in MCF-7 cells after treatment with the herbal extract. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1003508-2 | |
| Safety | NA |