| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1348 | |
| Phytochemical name or plant extracts | Pistacia atlantica sub kurdica extract | |
| PMID | 23351343 | |
| Literature evidence | More recently, we have shown that the pericarp methanolic extract of Pistacia atlantica sub kurdica (with local name of Baneh) as a rich source of active biological components with high antioxidant and radical scavenging activities, has ability to cease proliferation and induce apoptosis in T47D human breast cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Pistacia atlantica | |
| Geographical availability | Afghanistan, Algeria, Canary Is., Cyprus, East Aegean Is., Greece, Iran, Iraq, Krym, Lebanon-Syria, Libya, Morocco, North Caucasus, Pakistan, Palestine, Saudi Arabia, Sinai, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin D1, Caspase 3, p53 , CDK4, Cyclin-D1 | |
| Gene or Protein evidence | Taken together, our results establish that the antitumor activity of the pericarp extract of Baneh partly is mediated via cell cycle arrest and downregulation of cyclin D1 and cdk4 expression. The result showed that Baneh gum (100 µg/mL) significantly induced cell damage, activated caspase3, and increased P53 protein level Cyclin-D1 was significantly decreased in gum-incubated cells | |
| Target pathways | Inhibition of signal transduction proteins in the pathways linked to activation of NF-kappaB, in part is responsible for the cell cycle arrest and remarkable cyclin D1 reduction induced by Baneh extract in T47D cells | |
| IC50 | 1 mg/ml against T47D | |
| Potency | NA | |
| Cell line/ mice model | T47D | |
| Additional information | Overall, our results clearly indicate that Baneh extract as a potent and novel natural anticancer agent able to cease cell cycle progression of T47D cells at G0/G1 phase associated with downregulation of cyclin D1 by increasing the exposure time. | |
| PubChem ID | NA | |
| Additional PMIDs | 32184861 33548319 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:70236-1 | |
| Safety | LC50- 26.83 ± 0.11 ?M (MDA-MB-231) |