| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-831 | |
| Phytochemical name or plant extracts | Pinostrobin chalcone | |
| PMID | 21240148 | |
| Literature evidence | Flavokawin B (1), 5,6-dehydrokawain (2), pinostrobin chalcone (3) and alpinetin (4), isolated from the active ethyl acetate extract were also evaluated for their cytotoxic activity. | |
| IUPAC name | (E)-1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenylprop-2-en-1-one | |
| Phytochemicals’ class or type of plant extracts | Chalcone | |
| Source of phytochemicals or plant Extracts | Alpinia mutica | |
| Geographical availability | Borneo, India, Jawa, Malaya, Myanmar, Sulawesi, Thailand, Vietnam | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 7.3 µg/mL against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | KB, MCF-7, A549, Caski, HCT116, HT29 | |
| Additional information | Under in vitro enzymatic condition, the synthesized BrPT2 successfully catalyzed pinostrobin chalcone to pinostrobin. Molecular docking analysis showed that pinostrobin chalcone interacts with BrPT2 at two cavities: (1) the main binding site at the central cavity and (2) the allosteric binding site located away from the central cavity. | |
| PubChem ID | 5316793 | |
| Additional PMIDs | 33565047 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:795340-1 | |
| Safety | NA |