| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1155 | |
| Phytochemical name or plant extracts | Pinolenic acid | |
| PMID | 25213948 | |
| Literature evidence | Thus, PNA represents a potential anti-cancer agent. | |
| IUPAC name | (5Z,9Z,12Z)-octadeca-5,9,12-trienoic acid | |
| Phytochemicals’ class or type of plant extracts | Polyunsaturated fatty acid | |
| Source of phytochemicals or plant Extracts | Pinus koraiensis | |
| Geographical availability | Amur, Japan, Khabarovsk, Korea, Manchuria, Primorye | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | COX-2 | |
| Gene or Protein evidence | The results show that COX-2 protein expression, at the transcriptional and translational levels, was significantly decreased when cells were incubated with 100 lM concentrations of PNA, DHA or EPA. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In this study, we determined whether PNA could modulate breast cancer cell proliferation and metastasis | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | PNA changed n−6 PUFA metabolism, and affected PGE2 production and COX-2 expression. PNA incorporation modulated PGE2 production and COX-2 expression, and markedly inhibited cell metastasis through the suppression of both cell invasiveness and motility, | |
| PubChem ID | 5312495 | |
| Additional PMIDs | 15357026 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:263037-1 | |
| Safety | NA |