| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-442 | |
| Phytochemical name or plant extracts | Pinocembrin | |
| PMID | 31362371 | |
| Literature evidence | Our findings demonstrate the potential applicability of C. kirkii as a source of antimalarial and anticancer agents. | |
| IUPAC name | (2S)-5,7-dihydroxy-2-phenyl-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Glycyrrhiza glabra | |
| Geographical availability | Afghanistan, Albania, Bulgaria, Central European Rus, China North-Central, Cyprus, East Aegean Is., East European Russia, Greece, Iran, Iraq, Italy, Kazakhstan, Kirgizstan, Krym, Lebanon-Syria, Mongolia, North Caucasus, Pakistan, Palestine, Romania, Sardegna, Saudi Arabia, Sicilia, South European Russi, Tadzhikistan, Transcaucasus, Turkey, Turkmenistan, Ukraine, Uzbekistan, West Siberia, Xinjiang, Yugoslavia | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | Cyclin B1, Cdc2, PARP-1, Bcl-2, Survivin, PARP-1, Caspase 3, Caspase 9, Bax, ABCG2 | |
| Gene or Protein evidence | PCB downregulated the expression levels of proteins involved in cell cycle progression and apoptosis, including cyclinB1, Cdc2, PARP1, Bcl-2, and survivin, and upregulated protein levels of cleaved PARP1, cleaved caspase3, cleaved caspase9, and BAX. Chrysoeriol, laricitrin, myricetin 3',4',5'-trimethylether, pinocembrin, quercitrin, tamarixetin, tricetin and tricetin 3',4',5'-trimethylether were also identified as novel flavonoid ABCG2 inhibitors. | |
| Target pathways | PI3K/AKT Signaling Pathway | |
| IC50 | 13.2 µM against MDA-MB-231 | |
| Potency | Inhibition of the proliferation of BC cells by PCB involved cell cycle (G2/M phase) arrest and apoptosis in vitro and in vivo. Low concentrations of PCB also significantly inhibited the migration and invasion abilities of BC cells. These findings suggest that PCB might be an effective agent for treatment of BC patients. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, HeLa | |
| Additional information | Accumulative evidence suggests that the use of flavonoids, such as the antioxidative Pinocembrin (Pin), could be effective in the prevention of Dox-induced cardiotoxicity. | |
| PubChem ID | 68071 | |
| Additional PMIDs | 23497885 31284642 31362402 25643642 27509964 27123037 28850929 31222938 31311327 31491838 32903793 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:496941-1 | |
| Safety | NA |