| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1276 | |
| Phytochemical name or plant extracts | Pink Lady apples' flesh-flavonoids (Flesh-F) | |
| PMID | 26416794 | |
| Literature evidence | Meanwhile, both the Peel-F and Flesh-F can inhibit cancer cell growth in a dose-dependent manner, with the IC50 values of 110.33 ± 2.52 mg mL(-1) and 378.14 ± 1.64 mg mL(-1) for LoVo cells and 58.42 ± 1.39 mg mL(-1) and 296.06 ± 3.71 mg mL(-1) for MCF-7 cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Malus domestica 'Cripps Pink' | |
| Geographical availability | Afghanistan, Kazakhstan, Kirgizstan, Pakistan, Tadzhikistan, Uzbekistan, Xinjiang | |
| Plant parts | Flesh | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 296.06 ± 3.71 mg/mL against MCF-7 | |
| Potency | Moreover, we also found that the generation of ROS is a critical mediator in apple flavonoid-induced cell apoptosis and the induction effect of the Peel-F was significantly higher than that of the Flesh-F. | |
| Cell line/ mice model | LoVo, MCF-7 | |
| Additional information | It was found that the antioxidative property of the peel-flavonoids (Peel-F) was more effective than that of the flesh-flavonoids (Flesh-F). | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:726282-1 | |
| Safety | NA |