| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-518 | |
| Phytochemical name or plant extracts | Piceatannol (PCT)/(PIC) | |
| PMID | 33684694 | |
| Literature evidence | Examination of cell cycle phases displayed cells accumulation in G2-M phase and increased percentage cells in pre-G1 phase indicating an apoptosis-enhancing activity. | |
| IUPAC name | 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol | |
| Phytochemicals’ class or type of plant extracts | Stilbene | |
| Source of phytochemicals or plant Extracts | Sophora interrupta | |
| Geographical availability | India | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Hence, the estrogenic activity of PIC and MYR might be considered at least as a potential factor in the association of red wine intake and breast tumors, particularly in postmenopausal women. | |
| Cell line/ mice model | MCF-7, SKBR-3 | |
| Additional information | PCT-ZN NSs pro-apoptotic activity was confirmed by the observed significant increased mRNA expression of CASP3, p53, and Bax as well as decreased expression of Bcl2. In addition, PCT-ZN NSs induced oxidative stress as evidenced by depletion of glutathione reductase (GR) activity, increased generation of reactive oxygen species (ROS) and accumulation of lipid peroxidation products. Conclusively, ZN nanostructures of PCT revealed superior cell death-inducing activities against MCF-7 cells in comparison with free PCT. This is mediated, at least partly, by enhanced cellular uptake, pro-apoptotic activity, and oxidative stress potential. | |
| PubChem ID | 667639 | |
| Additional PMIDs | 16216908 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:518859-1 | |
| Safety | NA |