| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1571 | |
| Phytochemical name or plant extracts | Phytofluene | |
| PMID | 17051425 | |
| Literature evidence | Lycopene and other carotenoids inhibit estrogenic activity of 17beta-estradiol and genistein in cancer cells. | |
| IUPAC name | (6E,10E,12E,14E,16E,18E,22E,26E)-2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,10,12,14,16,18,22,26,30-decaene | |
| Phytochemicals’ class or type of plant extracts | Terpenoid | |
| Source of phytochemicals or plant Extracts | Hibiscus syriacus | |
| Geographical availability | China South-Central, China Southeast, Taiwan | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Uterus cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | However, each of the tested carotenoids (lycopene, phytoene, phytofluene, and beta-carotene) inhibited cancer cell proliferation induced by either E(2) or genistein. | |
| Cell line/ mice model | T47D, MCF-7, ECC-1 | |
| Additional information | In addition, phytofluene may prevent carcinogenesis by protecting cells against DNA damage through its free radical scavenger effects. Phytofluene due to its high photosensitizing activity might be considered as a promoter of cell photodamage and a promising UVA photosensitizer for medical purposes. | |
| PubChem ID | 6436722 | |
| Additional PMIDs | 33040721 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:560890-1 | |
| Safety | NA |