| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1459 | |
| Phytochemical name or plant extracts | Physalis minima extract | |
| PMID | 20150224 | |
| Literature evidence | The chloroform extract of Physalis minima produced a significant growth inhibition against human T-47D breast carcinoma cells as compared with other extracts with an EC(50) value of 3.8 microg/mL. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Chloroformic extract | |
| Source of phytochemicals or plant Extracts | Physalis minima | |
| Geographical availability | Alabama, Argentina Northeast, Argentina Northwest, Arizona, Aruba, Bahamas, Belize, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, California, Cayman Is., Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, French Guiana, Galápagos, Guatemala, Guyana, Haiti, Honduras, Jamaica, Kentucky, Leeward Is., Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Netherlands Antilles, New Mexico, Panamá, Paraguay, Peru, Puerto Rico, Southwest Caribbean, Suriname, Tennessee, Texas, Trinidad-Tobago, Uruguay, Venezuela, Windward Is. | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer, Ovarian cancer | |
| Target gene or protein | c-myc , p53, Caspase 3 | |
| Gene or Protein evidence | The c-myc was significantly induced by the chloroform extract at the earlier phase of treatment, followed by p53 and caspase-3. | |
| Target pathways | Induces apoptotic cell death via p53-, caspase-3-, and c-myc-dependent pathways (T-47D) Modulates c-myc, p53 and caspase-3 dependent pathways (Caov-3 cells) | |
| IC50 | NA | |
| Potency | The chloroform extract of Physalis minima produced a significant growth inhibition against human T-47D breast carcinoma cells as compared with other extracts with an EC(50) value of 3.8 microg/mL. | |
| Cell line/ mice model | T-47D, Caov-3 | |
| Additional information | Apoptotic effects of Physalis minima L. chloroform extract in human breast carcinoma T-47D cells mediated by c-myc-, p53-, and caspase-3-dependent pathways | |
| PubChem ID | NA | |
| Additional PMIDs | 24051023 20045455 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:315309-2 | |
| Safety | NA |