| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2020 | |
| Phytochemical name or plant extracts | Physagulide P | |
| PMID | 28969050 | |
| Literature evidence | Author information: (1)Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. (#)Contributed equally Physagulide P (PP), a new natural compound, was isolated from Physalis angulate L. in our laboratory. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Withanolide | |
| Source of phytochemicals or plant Extracts | Physalis angulate. | |
| Geographical availability | Alabama, Argentina Northeast, Argentina Northwest, Arizona, Aruba, Bahamas, Belize, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, California, Cayman Is., Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, French Guiana, Galápagos, Guatemala, Guyana, Haiti, Honduras, Jamaica, Kentucky, Leeward Is., Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Netherlands Antilles, New Mexico, Panamá, Paraguay, Peru, Puerto Rico, Southwest Caribbean, Suriname, Tennessee, Texas, Trinidad-Tobago, Uruguay, Venezuela, Windward Is. | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | JNK | |
| Gene or Protein evidence | PP also induced the generation of reactive oxygen species (ROS) and resulted in c-Jun N-terminal kinases (JNK) activation. Accordingly, JNK siRNA significantly attenuated PP-triggered apoptosis and autophagy, and ROS scavengers almost completely reverse this apoptosis and autophagy. | |
| Target pathways | ROS/JNK signaling pathway | |
| IC50 | NA | |
| Potency | Therefore, PP is a promising candidate for the development of antitumor drugs for the treatment of triple-negative breast cancer. | |
| Cell line/ mice model | MDA-MB-231, MDA-MB-468 | |
| Additional information | PP-treated cells also underwent autophagy, as evidenced by the formation of autophagosomes and the accumulation of LC3BII. Furthermore, the knockdown of LC3B reduced PP-induced cytotoxicity, indicating that autophagy played an anticancer effect. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:195334-2 | |
| Safety | NA |