| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1732 | |
| Phytochemical name or plant extracts | Phyllanthus amarus extract | |
| PMID | 19874864 | |
| Literature evidence | This study evaluated the effects of aqueous extract of Phyllanthus amarus Schum. & Thon. against Cr(VI)-induced oxidative toxicity in vitro in MDA-MB-435S human breast carcinoma cells, along with an estimation of its antioxidant potential, inhibition of lipid peroxidation and determination of its polyphenolic composition. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Phyllanthus amarus Schum & Thon | |
| Geographical availability | Argentina Northeast, Aruba, Bahamas, Belize, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Cayman Is., Chile North, Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, French Guiana, Guatemala, Guyana, Haiti, Honduras, Jamaica, Leeward Is., Mexico Gulf, Mexico Southeast, Mexico Southwest, Netherlands Antilles, Nicaragua, Panamá, Paraguay, Peru, Puerto Rico, Southwest Caribbean, Suriname, Trinidad-Tobago, Turks-Caicos Is., Uruguay, Venezuela, Windward Is. | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | The hairy root methanol extract of P. amarus was found to exhibit anti-proliferative effect on MCF-7 human breast cancer cells via induction of apoptosis by increasing ROS level as well as the reduction in mitochondrial membrane potential | |
| IC50 | NA | |
| Potency | It was concluded that P. amarus aqueous extract has high antioxidant potential (by virtue of its phenolic constituents) which simultaneously inhibits Cr(VI)-induced oxidative toxicity to MDA-MB-435S cells. | |
| Cell line/ mice model | MDA-MB-435S, MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 30081891 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:326408-2 | |
| Safety | NA |