| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1917 | |
| Phytochemical name or plant extracts | Phloridzin | |
| PMID | 28939230 | |
| Literature evidence | The optimal concentration of DPPH was determined, and six potential antioxidants including 4-hydroxyphenylacetic acid, p-coumaric acid, ferulic acid, quercitrin, astragalin, and quercetin, and three non-antioxidants including benzoic acid, coptisine, and berberine, were successfully screened out and validated by conventional DPPH radical scavenging activity assay. | |
| IUPAC name | 1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Malus pumila | |
| Geographical availability | Afghanistan, Kazakhstan, Kirgizstan, Pakistan, Tadzhikistan, Uzbekistan, Xinjiang | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | When added with 17beta-estradiol, phloridzin showed antagonism on estradiol-induced MCF-7 cell proliferation, but it did not significantly affect proliferation of estrogen insensitive ER (-)MDA-MB-231 cells. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | The uptake of GHB in rat MCT1 gene-transfected MDA-MB231 cells was significantly decreased in the presence of the flavonoids apigenin, biochanin A, chrysin, diosemin, fisetin, genistein, hesperitin, kaempferol, luteolin, morin, narigenin, phloretin, and quercetin, but was not affected by the flavonoid glycosides phloridzin and rutin. It has many pharmacological activities, such as regulating blood sugar level and blood pressure, protecting heart, scavenging of oxygen free radicals and antioxidant injuries. Thus, market demand of products containing phloridzin is increasing year by year. Our investigation proved that phloridzin was distributed at the target organ and played the role of phytoestrogen. | |
| PubChem ID | 6072 | |
| Additional PMIDs | 31473253 33288802 17108059 20410591 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:726372-1 | |
| Safety | NA |