| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1975 | |
| Phytochemical name or plant extracts | Pheophorbide-a | |
| PMID | 20558270 | |
| Literature evidence | Pheophorbide-a (Pa), one of the active components isolated from this herbal medicine has been proposed to be a potential natural photosensitizer for photodynamic therapy. | |
| IUPAC name | 3-(16-ethenyl-11-ethyl-4-hydroxy-3-methoxycarbonyl-12,17,21,26-tetramethyl-7,23,24,25-tetrazahexacyclo[18.2.1.15,8.110,13.115,18.02,6]hexacosa-1,4,6,8(26),9,11,13(25),14,16,18(24),19-undecaen-22-yl)propanoic acid | |
| Phytochemicals’ class or type of plant extracts | Pheophorbide-a (Pa), one of the active components isolated from this herbal medicine has been proposed to be a potential natural photosensitizer for photodynamic therapy (Pa-PDT). | |
| Source of phytochemicals or plant Extracts | Scutellaria barbata | |
| Geographical availability | Assam, Bangladesh, China South-Central, China Southeast, East Himalaya, Japan, Korea, Laos, Myanmar, Nepal, Taiwan, Thailand, Vietnam, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | JNK, ERK | |
| Gene or Protein evidence | Activation of c-Jun N-terminal kinase (JNK) and inhibition of extracellular signal-regulated kinase (ERK) were occurred in the Pa-PDT-treated cells. | |
| Target pathways | Mitogen-activated protein kinase (MAPK) pathway was found to be triggered. | |
| IC50 | 0.5 μM at 24h against MDA-MB-231 | |
| Potency | Our findings suggested that Pa-PDT exhibited its anti-tumor effects by the activation of mitochondria-mediated apoptosis and the ERK-mediated autophagy in MDA-MB-231 cells. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | The present study suggested Pa-PDT is a potential protocol for the late phase human breast cancer, and it is the first study to demonstrate the Pa-PDT induced autophagy contributed to the anti-tumor effects of Pa-PDT on human cancer cells. | |
| PubChem ID | 167186 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:458159-1 | |
| Safety | NA |