| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1597 |
| Phytochemical name or plant extracts | Phenylacetaldehyde |
| PMID | 33202749 |
| Literature evidence | Our results suggest that the PAA-induced ROS deregulated Stat3/IL-6 pathway and PAA may be a potential agent targeting breast cancer and CSCs. |
| IUPAC name | 2-phenylacetaldehyde |
| Phytochemicals’ class or type of plant extracts | Flower flavor |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | Flowers |
| Other cancers | Breast cancer |
| Target gene or protein | STAT-3, IL-6 |
| Gene or Protein evidence | PAA reduced phosphorylation of nuclear Stat3. PAA inhibited Stat3 signaling through de-phosphorylation of Stat3 and reduced secretory IL-6. |
| Target pathways | PAA can be used in breast cancer treatment by targeting CSCs via the ROS/Stat3/IL-6 signal pathway |
| IC50 | 550 µM against MDA-MB-231 606 µM against MCF-7 |
| Potency | Our results showed PAA inhibits tumor growth in the in vivo mouse model. Our data suggest that PAA is useful for breast cancer treatment and the Stat3/IL-6 signal as a marker for CSCs targeting. |
| Cell line/ mice model | MCF-7, MDA-MB-231 |
| Additional information | PAA had anti-proliferation and induced cell apoptosis. PAA reduced cell migration and colony formation of breast cancer. PAA inhibits in vivo tumor growth. PAA reduced size and formation of the mammosphere. PAA reduced CD44+/CD24? and ALDH-expression cells. PAA induced ROS production and decrease of mammosphere formation. PAA inhibits the mammosphere formation by blocking Stat3 signal. |
| PubChem ID | 998 |
| Additional PMIDs | NA |
| Additional sources of information | NA |
| Safety | NA |