| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1142 | |
| Phytochemical name or plant extracts | Phenethyl Isothiocyanate | |
| PMID | 31307507 | |
| Literature evidence | Our studies provide the first evidence that PEITC's anti-cancer activity is cancer cell type-independent, but p53 mutant-type dependent. | |
| IUPAC name | 2-isothiocyanatoethylbenzene | |
| Phytochemicals’ class or type of plant extracts | Isothiocyanate | |
| Source of phytochemicals or plant Extracts | Nasturtium officinale | |
| Geographical availability | Afghanistan, Albania, Algeria, Austria, Azores, Baleares, Belgium, Bulgaria, Canary Is., Cape Verde, Central European Rus, Chad, Corse, Cyprus, Czechoslovakia, East Aegean Is., Egypt, Ethiopia, France, Germany, Greece, Hungary, Iran, Iraq, Ireland, Italy, Kazakhstan, Kirgizstan, Kriti, Krym, Libya, Madeira, Morocco, Netherlands, North Caucasus, Pakistan, Palestine, Poland, Portugal, Romania, Sardegna, Saudi Arabia, Sicilia, Sinai, Spain, Sudan, Sweden, Switzerland, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, West Himalaya, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Prostate cancer, Lung cancer, Liver cancer, Colon cancer | |
| Target gene or protein | MTDH , CDH1, TSC2, sfRON | |
| Gene or Protein evidence | We found that phenethyl isothiocyanate (PEITC), a well-known pro-oxidant phytochemical, suppressed stemness in MDA-MB-231/IR cells through ROS modulation via the downregulation of MTDH. Phenethyl isothiocyanate reduces breast cancer stem cell-like properties by epigenetic reactivation of CDH1. 3) Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2. On the other hand, activation of Bax and Bak following BITC exposure was markedly more pronounced in sfRON overexpressing cells than in controls. sfRON overexpression also augmented apoptosis induction by structurally diverse cancer chemopreventive phytochemicals including withaferin A, phenethyl isothiocyanate, and D,L-sulforaphane. | |
| Target pathways | Taken together, these results suggest that PEITC inhibits the HIF-1α expression through inhibiting the PI3K and MAPK signalling pathway and provide a new insight into a potential mechanism of the anticancer properties of PEITC. | |
| IC50 | 7.32 +/- 0.25 µmol/L against MCF-7 | |
| Potency | Surprisingly, we observed that PEITC suppressed the HIF-1α accumulation during hypoxia in human glioma U87, human prostate cancer DU145, colon cancer HCT116, liver cancer HepG2, and breast cancer SkBr3 cells. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, PC-3, DU145, U87, HCT116, HepG2, SKBR-3 | |
| Additional information | Furthermore, we show that cells with p53 mutations are more sensitive to cytotoxicity induced by phenethyl isothiocyanate (PEITC) than those with the wild-type protein. 2,2-Diphenylethyl ITC, a synthetic ITC, is one of the most potent depletors of mutant p53 studies and induces apoptosis to the greatest extent in mutant p53 breast cancer cells. | |
| PubChem ID | 16741 | |
| Additional PMIDs | 22859850 25857724 30066177 31600949 31979093 22607231 15337839 15176077 15648258 19144873 31307507 21241062 21739479 23682784 21595016 22351438 23870899 25949878 33416137 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:287534-1 | |
| Safety | NA |