| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1154 | |
| Phytochemical name or plant extracts | Peucedanum japonicum Thunb (PJT) extract | |
| PMID | 26717978 | |
| Literature evidence | The results indicated that the PJT-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involved the suppression of the PKCα/NF-κB pathway in MCF-7 cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanol extract | |
| Source of phytochemicals or plant Extracts | Peucedanum japonicum | |
| Geographical availability | China North-Central, China Southeast, Japan, Korea, Nansei-shoto, Philippines, Taiwan | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP9 | |
| Gene or Protein evidence | The results indicated that the PJT-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involved the suppression of the PKCα/NF-κB pathway in MCF-7 cells. | |
| Target pathways | PKCα/NF-κB pathway | |
| IC50 | NA | |
| Potency | Thus, the inhibition of MMP-9 expression by PJT may have potential value as a therapy for restricting the invasiveness of breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | PJT ethanol extract increased the expression of the UCP3 gene in muscle. These results suggest that the anti-obesity phytochemicals in PJT lower lipid levels by inhibiting fat absorption and by modulating obesity-related gene expression in the liver, adipose tissue, and muscle. | |
| PubChem ID | NA | |
| Additional PMIDs | 22277893 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:846161-1 | |
| Safety | NA |