| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-258 | |
| Phytochemical name or plant extracts | Persin | |
| PMID | 16985064 | |
| Literature evidence | Here we describe the characterization of a novel plant toxin, persin, with in vivo activity in the mammary gland and a p53-, estrogen receptor-, and Bcl-2-independent mode of action. | |
| IUPAC name | [(12Z,15Z)-2-hydroxy-4-oxohenicosa-12,15-dienyl] acetate | |
| Phytochemicals’ class or type of plant extracts | Long chain fatty alcohol | |
| Source of phytochemicals or plant Extracts | Persea americana | |
| Geographical availability | Belize, Costa Rica, Guatemala, Honduras, Mexico Central, Mexico Gulf, Mexico Southeast, Mexico Southwest, Nicaragua | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | IC50 ∼55 μmol/Lagainst MDA-MB-231 IC50 ∼6.9 μmol/L against MCF-7, T47D | |
| Potency | Due to the unique structure of the compound, persin could represent a novel class of microtubule-targeting agent with potential specificity for breast cancers. | |
| Cell line/ mice model | MCF-7, T-47D, MDA-MB-231 | |
| Additional information | Further in vitro studies in a panel of human breast cancer cell lines show that persin selectively induces a G2-M cell cycle arrest and caspase-dependent apoptosis in sensitive cells. The latter is dependent on expression of the BH3-only protein Bim. Bim is a sensor of cytoskeletal integrity, and there is evidence that persin acts as a microtubule-stabilizing agent. | |
| PubChem ID | 5283266 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:325643-2 | |
| Safety | NA |