| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-24 | |
| Phytochemical name or plant extracts | Periploca hydaspidis Falc crude extract | |
| PMID | 34588860 | |
| Literature evidence | Overall, our results conclude that PHM can inhibit cell-proliferation and induce apoptotic effects by activation of P38 MAPK cell-signaling pathway. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Periploca hydaspidis | |
| Geographical availability | India, Pakistan, West Himalaya | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | Survivin, Bcl-xL, XIAP, Myelocytomatosis, C-myc, MMP2, MMP9, Cyclin D1, Cyclin E, Bak, Bax, Caspase 3 , Caspase 7, Caspase 8, Caspase 9, PARPB | |
| Gene or Protein evidence | PHM induced apoptosis via downregulation of anti-apoptotic (survivin, B-cell lymphoma Extra-large, BCL-XL, X-linked inhibitor of apoptosis protein, XIAP, Myelocytomatosis, C-myc), metastatic (Matrix metallopeptidases 9/2, MMP9/2), and cell-cycle regulatory (cyclin D1 and E) proteins, whereas upregulation of pro-apoptotic proteins (Bcl-2 homologous antagonist/killer, BAK, Bcl-2-Associate X protein, BAX, cleaved caspases, 3,7,8,9, and PARP) | |
| Target pathways | P38 MAPK cell-signaling pathway | |
| IC50 | NA | |
| Potency | Significant activity was brought forward by both PHM and PHE alongside MCF-7 corresponding to 199 ± 0.64, 120 ± 0.92, 95.8 ± 0.53 and 440 ± 5.31, 284 ± 4.07, 202 ± 2.97 μg/ml at 24, 48, and 72 h’, respectively | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HCCLM3 | |
| Additional information | This suggests the methanol fraction of P. hydaspidis (PHM) to have anticancer compounds, potentially useful for treating liver and breast cancer. MTT assay displayed a significant antiproliferative potential of PHAgNPs against HCCLM3, MCF-7, MDA-MB 231, and HEPG2 cancer cell lines, where least IC50 values were recorded against HEPG2 (12.97 ± 0.04 μg/mL) and MCF-7 (5.73 ± 0.22 μg/mL). | |
| PubChem ID | NA | |
| Additional PMIDs | 33880837 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:100463-1 | |
| Safety | NA |