| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-907 | |
| Phytochemical name or plant extracts | Perillyl alcohol | |
| PMID | 9824849 | |
| Literature evidence | Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines. | |
| IUPAC name | (4-prop-1-en-2-ylcyclohexen-1-yl)methanol | |
| Phytochemicals’ class or type of plant extracts | Monoterpene | |
| Source of phytochemicals or plant Extracts | Trachyspermum anethifolium | |
| Geographical availability | East Himalaya, Nepal, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin D1 mRNA | |
| Gene or Protein evidence | Finally, we showed that the effects of limonene-related monoterpenes on cell proliferation and cell cycle progression were preceded by a decrease in cyclin D1 mRNA levels. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Of the three monoterpenes tested, perillyl alcohol was the most potent and limonene was the least potent inhibitor of cell growth. | |
| Cell line/ mice model | T47D, MCF-7, MDA-MB-231 | |
| Additional information | Sensitivity of breast cancer cell lines to monoterpenes was in the following order: T-47D > MCF-7 > MDA-MB-231. Growth inhibition induced by perillyl alcohol and perillic acid was associated with a fall in the proportion of cells in the S phase and an accumulation of cells in the G1 phase of the cell cycle. | |
| PubChem ID | 10819 | |
| Additional PMIDs | 19820395 8886131 15569989 15570061 7587953 9824849 17885756 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:849766-1 | |
| Safety | NA |