| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-126 | |
| Phytochemical name or plant extracts | Perillic acid | |
| PMID | 9824849 | |
| Literature evidence | Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines. | |
| IUPAC name | 4-prop-1-en-2-ylcyclohexene-1-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Monoterpene | |
| Source of phytochemicals or plant Extracts | Perilla frutescens | |
| Geographical availability | Assam, Bangladesh, China South-Central, China Southeast, East Himalaya, India, Japan, Jawa, Khabarovsk, Korea, Laos, Myanmar, Nepal, Primorye, Taiwan, Thailand, Vietnam, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin D1 mRNA | |
| Gene or Protein evidence | Finally, we showed that the effects of limonene-related monoterpenes on cell proliferation and cell cycle progression were preceded by a decrease in cyclin D1 mRNA levels. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | To a lesser extent, perillic acid affected MCF-7 cell growth, which was reduced by 16% at 50 ^M and by 66% at 3 mM. MDA-MB231 cell growth was only slightly affected by perillic acid, which reduced cell proliferation by 26% at a concentration of 3 mM. In the least-sensitive MDA-MB-231 cells, a maximum decrease in proliferation of 32% was observed after seven days of treatment with 3 mM perillic acid. | |
| Cell line/ mice model | T47D, MCF-7, MDA-MB-231 | |
| Additional information | Sensitivity of breast cancer cell lines to monoterpenes was in the following order: T-47D > MCF-7 > MDA-MB-231. Growth inhibition induced by perillyl alcohol and perillic acid was associated with a fall in the proportion of cells in the S phase and an accumulation of cells in the G1 phase of the cell cycle. | |
| PubChem ID | 1256 | |
| Additional PMIDs | 7987974 7587953 9824849 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:190343-2 | |
| Safety | NA |