| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2070 | |
| Phytochemical name or plant extracts | Pergularia tomentosa extract | |
| PMID | 33576214 | |
| Literature evidence | These extracts can be used as natural antitumor. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract and Latex (milky secretion) extract | |
| Source of phytochemicals or plant Extracts | Pergularia tomentosa | |
| Geographical availability | Afghanistan, Algeria, Benin, Burkina, Chad, Djibouti, Egypt, Ethiopia, Gulf States, Iran, Lebanon-Syria, Libya, Mali, Mauritania, Morocco, Niger, Nigeria, Oman, Pakistan, Palestine, Saudi Arabia, Sinai, Socotra, Somalia, Sudan, Tunisia, Western Sahara, Yemen | |
| Plant parts | Stem | |
| Other cancers | Breast cancer, Colon cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | Methanol extract - IC50 = 29.5μg/ml against MCF-7 Milky secretion extract - IC50 = 120 µg/ml against MCF-7 | |
| Potency | Methanolic extract was strong cytotoxic activity against HCT-116 and HepG2 (IC50= 10.2, 13.6 µg/ml, respectively) and moderately activity against MCF-7 (IC50= 29.5 µg/ml). The Milky extract exhibited moderate activity against HCT-116 and HepG2 (IC50= 52.6-58.6 µg/ml, respectively) and weak activity against MCF-7 (120.0 µg/ml). | |
| Cell line/ mice model | HCT-116, HepG2, MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:100411-1 | |
| Safety | NA |