| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-240 | |
| Phytochemical name or plant extracts | Peonidin-3-glucoside | |
| PMID | 24312561 | |
| Literature evidence | They inhibit the phospho-HER2 and phospho-AKT and were confirmed to induce HER2-psotive breast cancer cells apoptosis both in vitro and in vivo. | |
| IUPAC name | (2S,3R,4S,5S,6R)-2-[5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromenylium-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Oryza sativa | |
| Geographical availability | China North-Central, China South-Central, China Southeast | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | HER2, AKT | |
| Gene or Protein evidence | They inhibit the phospho-HER2 and phospho-AKT and were confirmed to induce HER2-psotive breast cancer cells apoptosis both in vitro and in vivo. | |
| Target pathways | NA | |
| IC50 | 5.2±0.8µM against BT-474 4.3±0.6µM against HCC1569 1.2±0.5µM against MDA-MB-453 | |
| Potency | Western blotting show that both peonidin-3-glucoside and cyanidin-3-glucoside significantly reduce the phospho-HER2, phospho-AKTs, and phopspho-p44/42MAPK levels compared to control cells | |
| Cell line/ mice model | BT-474, HCC1569, MDA-MB-453, 6–7-week-old female nude mice | |
| Additional information | Peonidin-3-glucoside and cyaniding-3-glucoside treatments significantly reduced the tumor size and volume in vivo compared to the control group. There is no significant difference of antitumorgenic effects between peonidin-3-glucoside and cyaniding-3-glucoside treatments. | |
| PubChem ID | 443654 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:316812-2 | |
| Safety | NA |