| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1718 | |
| Phytochemical name or plant extracts | Pentadecanoic acid | |
| PMID | 32503225 | |
| Literature evidence | Moreover, pentadecanoic acid reduced the stemness of MCF-7/SC and suppressed the migratory and invasive ability of MCF-7/SC as evidenced by the results of flow cytometry, a mammosphere formation assay, an aldehyde dehydrogenase activity assay, and Western blot experiments conducted to analyze the expression of cancer stem cell markers-CD44, β-catenin, MDR1, and MRP1-and epithelial-mesenchymal transition (EMT) markers-snail, slug, MMP9, and MMP2. | |
| IUPAC name | pentadecanoic acid | |
| Phytochemicals’ class or type of plant extracts | Saturated fatty acid | |
| Source of phytochemicals or plant Extracts | Staphisagria macrosperma | |
| Geographical availability | Albania, Algeria, Baleares, Corse, Cyprus, East Aegean Is., France, Greece, Italy, Kriti, Lebanon-Syria, Morocco, Portugal, Sardegna, Sicilia, Spain, Tunisia, Turkey, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 7, caspase 8, caspase 9, β-catenin, MDR1, MRP1-and epithelial-mesenchymal transition (EMT) markers-snail, slug, MMP9, MMP2. | |
| Gene or Protein evidence | According to the Western blot experiment results, pentadecanoic acid exposure resulted in an increase in the expression of cleaved caspase-3, -7, -8, and -9 in MCF-7/SC, indicating that pentadecanoic acid can induce both the extrinsic and intrinsic apoptosis pathways. Moreover, pentadecanoic acid reduced the stemness of MCF-7/SC and suppressed the migratory and invasive ability of MCF-7/SC as evidenced by the results of flow cytometry, a mammosphere formation assay, an aldehyde dehydrogenase activity assay, and Western blot experiments conducted to analyze the expression of cancer stem cell markers-CD44, β-catenin, MDR1, and MRP1-and epithelial-mesenchymal transition (EMT) markers-snail, slug, MMP9, and MMP2. | |
| Target pathways | In addition, pentadecanoic acid suppressed interleukin-6 (IL-6)-induced JAK2/STAT3 signaling, induced cell cycle arrest at the sub-G1 phase, and promoted caspase-dependent apoptosis in MCF-7/SC. | |
| IC50 | NA | |
| Potency | These findings indicate that pentadecanoic acid can serve as a novel JAK2/STAT3 signaling inhibitor in breast cancer cells and suggest the beneficial effects of pentadecanoic acid-rich food intake during breast cancer treatments. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | 13849 | |
| Additional PMIDs | 34401594 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60456584-2 | |
| Safety | NA |