| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1864 | |
| Phytochemical name or plant extracts | Pelingo apple juice | |
| PMID | 26284516 | |
| Literature evidence | Pelingo juice induced cell accumulation in the G2/M phase of the cell cycle and autophagy through overexpression of p21, inhibition of extracellular signal-regulated kinases 1/2 (ERK1/2) activity and an increase in lipidated microtubule-associated protein-1 light chain-3 beta (LC3B). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Polyphenol | |
| Source of phytochemicals or plant Extracts | Pelingo apple | |
| Geographical availability | Pesaro-Urbino province, Central Italy | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | p21, ERK1/2, LC3B | |
| Gene or Protein evidence | Pelingo juice induced cell accumulation in the G2/M phase of the cell cycle and autophagy through overexpression of p21, inhibition of extracellular signal-regulated kinases 1/2 (ERK1/2) activity and an increase in lipidated microtubule-associated protein-1 light chain-3 beta (LC3B). | |
| Target pathways | The cytostatic effect of Pelingo juice it was confirmed by the inhibition of ERK1/2 activity and the upregulation of p21. ERK1 and ERK2 participate in the Ras-Raf-MEK-ERK signal transduction cascade, implicated in the regulation of a large variety of processes including cell adhesion, cell migration, cell cycle progression and proliferation, including the G2/M transition. | |
| IC50 | 3.96 ± 0.23% v/v against MCF-7 1.81 ± 0.09% v/v against MDA-MB-231 | |
| Potency | Our data indicate that the Pelingo apple is rich in food components that can markedly inhibit in vitro tumorigenesis and growth of human breast cancer cells and could provide natural bioactive non-nutrient compounds, with potential chemopreventive activity. | |
| Cell line/ mice model | MCF-7 , MDA-MB-231 | |
| Additional information | Pelingo juice inhibited the 12-o-tetra-decanoyl-phorbol-13-acetate (TPA)-induced tumorigenesis of JB6 P+ cells, suppressing colony formation in semi-solid medium and TPA-induced ERK1/2 phosphorylation. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |