| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-134 | |
| Phytochemical name or plant extracts | Pectolinarigenin | |
| PMID | 31649548 | |
| Literature evidence | Intraperitoneal administrations of pectolinarigenin significantly inhibited breast cancer metastasis to lungs without affecting the tumor growth of incubated 4T1 breast cancer cells. | |
| IUPAC name | 5,7-dihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Cirsium chanroenicum | |
| Geographical availability | Korea | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP2, MMP9, TIMP-2, STAT-3 | |
| Gene or Protein evidence | The results of western blot suggested that Pec. could significantly inhibit the expressions of MMP2, MMP-9, and p-Stat3, while up-regulating the expression of TIMP-2 without affecting the total Stat3 expression level in MCF-7, 4T1, and MDA-MB-231 cells | |
| Target pathways | STAT3 Signaling Pathway | |
| IC50 | 30.6±13.2 μM against MCF-7 for 48 hours 39.8±0.6 μM against 4T1 for 48 hours 23.1±5.5 μM against MDA-MB-231 for 48 hours 18.7±8.7μM against MCF-7 for 72 hours 15.7±0.6μM against 4T1 for 72 hours 14.9±1.8μM against MDA-MB-231 for 72 hours | |
| Potency | Pectolinarigenin might potentially be a candidate for metastasis of breast cancer by mediating Stat3 pathway. | |
| Cell line/ mice model | 4T1, MDA-MB-231, MCF-7 | |
| Additional information | We also found that pectolinarigenin inhibited breast cancer cell proliferation and induced apoptosis via mitochondrial-related apoptosis pathway, reduced mitochondrial membrane potential and the expression of Bcl-2, increased expression of Bax, and cleaved caspase-3 as well as disturbed the ROS generation. | |
| PubChem ID | 5320438 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:195181-1 | |
| Safety | NA |