| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-757 | |
| Phytochemical name or plant extracts | Pectic acid | |
| PMID | 26225664 | |
| Literature evidence | Many substancesmay induce apoptosis in anti-cancer treatment. | |
| IUPAC name | (2S,3R,4R,5R,6S)-3-[(2S,3R,4R,5R,6S)-6-carboxy-5-[(1S,2R,3S,4S,5S)-5-carboxy-2,3,4-trihydroxycyclohexyl]oxy-3,4-dihydroxyoxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Pectic-oligoshaccharide | |
| Source of phytochemicals or plant Extracts | Malus domestica | |
| Geographical availability | Afghanistan, Kazakhstan, Kirgizstan, Pakistan, Tadzhikistan, Uzbekistan, Xinjiang | |
| Plant parts | Peels | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | The data showed pectic acid induced caspase-dependent apoptosis | |
| IC50 | NA | |
| Potency | These data indicate that apple pectic acid without any modification could trigger apoptosis in MDA-MB-231 human breast cancer cells and has potential to improve cancer treatment as a natural product. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Pectic acid could stimulate the release of PRL in GH3/B6 cells in the short-term incubation. This result suggested that pectic acid is a non-toxic agent that could directly stimulate PRL secretion in pituitary cells without any interference of hypophysis. | |
| PubChem ID | 156614133 | |
| Additional PMIDs | 18762820 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:726282-1 | |
| Safety | NA |