| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-808 | |
| Phytochemical name or plant extracts | Patrinia scabiosaefolia extract (EAE-PS) | |
| PMID | 16361073 | |
| Literature evidence | Although Patrinia scabiosaefolia has also been suggested for cancer therapy, there has not been any scientific evidence supporting this application. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethyl acetate extract | |
| Source of phytochemicals or plant Extracts | Patrinia scabiosaefolia | |
| Geographical availability | Amur, China North-Central, China South-Central, China Southeast, Chita, Inner Mongolia, Japan, Khabarovsk, Korea, Kuril Is., Manchuria, Mongolia, Nansei-shoto, Primorye, Sakhalin, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Bcl-xL | |
| Gene or Protein evidence | Ethyl acetate extract of Patrinia scabiosaefolia downregulates anti-apoptotic Bcl-2/Bcl-X(L) expression, and induces apoptosis in human breast carcinoma MCF-7 cells independent of caspase-9 activation | |
| Target pathways | NA | |
| IC50 | 112.3 μg/ml against MCF-7 | |
| Potency | Results from this study support future research and development of the bioactive ingredients from Patrinia scabiosaefolia as anticancer agents, especially against those apoptosis-resistant cancers with deregulated Bcl-2/Bcl-X(L) expression. | |
| Cell line/ mice model | MCF-7, HepG2, A375, A549, PC-3 | |
| Additional information | All these results suggest that EAE-PS retards MCF-7 cell growth by activating the caspase-independent mitochondrial cell death pathway. | |
| PubChem ID | NA | |
| Additional PMIDs | 33855012 16361073 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77226205-1 | |
| Safety | NA |