| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2189 | |
| Phytochemical name or plant extracts | Parvifloron D | |
| PMID | 31963771 | |
| Literature evidence | Moreover, for the first time we have shown that ParvD reduces cell motility, unraveling potential anti-metastatic properties. | |
| IUPAC name | [(3S,4aS)-5-hydroxy-1,1,4a-trimethyl-6-oxo-7-propan-2-yl-3,4-dihydro-2H-phenanthren-3-yl] 4-hydroxybenzoate | |
| Phytochemicals’ class or type of plant extracts | Abietane diterpenoid | |
| Source of phytochemicals or plant Extracts | Plectranthus ecklonii | |
| Geographical availability | Cape Provinces, KwaZulu-Natal, Northern Provinces | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Leukemia, Melanoma | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 2.48 µM against MDA-MB-231 | |
| Potency | This is the first report describing the proapoptotic effect of ParvD in TNBC cells. Moreover, for the first time we have shown that ParvD reduces cell motility, unraveling potential anti-metastatic properties. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | ParvD 5 µM showed a significant pro-apoptotic effect in MDA-MB-231 cells after periods of 24 and 48 h of incubation, increasing the % of apoptotic cells by 2.5- and 2.9-fold, respectively. | |
| PubChem ID | 101967011 | |
| Additional PMIDs | 31627339 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:454370-1 | |
| Safety | NA |