| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2160 | |
| Phytochemical name or plant extracts | Paris saponin VII | |
| PMID | 24818584 | |
| Literature evidence | Saponins of several herbs are known to induce apoptosis in some cancer cells and are proposed to be promising modulators of drug resistance. | |
| IUPAC name | (2S,3R,4R,5R,6S)-2-[(2S,3R,4S,5R,6S)-4,5-dihydroxy-6-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1R,2S,4S,5'R,6R,7S,8S,9S,12S,13R,16S)-8-hydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxy-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-2-methyloxan-3-yl]oxy-6-methyloxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Saponin | |
| Source of phytochemicals or plant Extracts | Trillium tschonoskii | |
| Geographical availability | China North-Central, China South-Central, China Southeast, East Himalaya, Japan, Korea, Kuril Is., Myanmar, Sakhalin, Taiwan, Tibet | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NFR1, TRAIL R1/DR4, TRAIL R2/DR5, FADD, PARP, Caspase 8, Caspase 3, P-gp | |
| Gene or Protein evidence | Further results showed that PS VII treatment in MCF-7/ADR cells led to increased TNFR1, TRAIL R1/DR4, TRAIL R2/DR5, and FADD expression, and activation of PARP, caspase-8, and 3. In parallel to the alterations, P-glycoprotein expression and activity were also reduced. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These findings showed that PS VII might be an effective tumouristatic agent for the treatment of MDR breast cancer. | |
| Cell line/ mice model | MCF-7/ADR | |
| Additional information | PS VII dose dependently suppressed cell viability as well as triggered apoptosis and modulated drug resistance of MCF-7/ADR cells. | |
| PubChem ID | 176233 | |
| Additional PMIDs | 30552993 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:542611-1 | |
| Safety | NA |