| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-294 | |
| Phytochemical name or plant extracts | Paratocarpin E | |
| PMID | 27814565 | |
| Literature evidence | Mechanistically, cell death induced by paratocarpin E is able to induce apoptosis of MCF-7 cells by activating p38 and JNK signaling pathway while inhibiting Erk pathway. | |
| IUPAC name | (E)-1-[2,4-dihydroxy-3-(2-hydroxy-3-methylbut-3-enyl)phenyl]-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Euphorbia humifusa | |
| Geographical availability | Altay, Amur, Buryatiya, China North-Central, China South-Central, China Southeast, Chita, East European Russia, Hainan, Inner Mongolia, Iran, Irkutsk, Japan, Kazakhstan, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Krym, Manchuria, Mongolia, Nansei-shoto, North Caucasus, Primorye, Qinghai, Tadzhikistan, Taiwan, Tibet, Transcaucasus, Turkey, Tuva, Ukraine, Uzbekistan, West Siberia, Xinjiang, Yakutskiya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | p38 and JNK signaling pathway Erk pathway | |
| IC50 | 19.6μM against MCF7 | |
| Potency | These findings provide initial evidences that paratocarpin E can be used as a potential anti-cancer drug in future for breast cancer therapy. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Paratocarpin E promotes the activation and nuclear translocation of NF-κB, which plays an important role in balancing paratocarpin E-mediated apoptosis and autophagy. | |
| PubChem ID | 42607534 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:346840-1 | |
| Safety | NA |