| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1509 | |
| Phytochemical name or plant extracts | Papain | |
| PMID | 20952754 | |
| Literature evidence | Reduced side-effects of adjuvant hormone therapy in breast cancer patients by complementary medicine. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Plant enzyme | |
| Source of phytochemicals or plant Extracts | Carica papaya | |
| Geographical availability | Belize, Colombia, Costa Rica, El Salvador, Guatemala, Honduras, Mexico Gulf, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Venezuela | |
| Plant parts | Leaves, latex, Root, and Fruits. | |
| Other cancers | Breast cancer, Liver cancer, Prostate cancer, Skin cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 1319.25 µg/mL against MCF-7 | |
| Potency | Our results with purified and fully active bromelain, ananain and papain show a strong reduction of cell proliferation with MDA-MB231 and A2058 cancer cell lines at a concentration of about 1 ?M, control experiments clearly emphasizing the need for proteolytic activity. | |
| Cell line/ mice model | MDA-MB-231, A2058, MCF-7 | |
| Additional information | The severity of side-effects of HT was reduced by complementary treatment with sodium selenite, plant enzymes (bromelaine and papain) and Lens culinaris lectin. The maximum inhibition on MCF-7 cancer cells (92.37% at 1 mg/mL) was achieved by papain hydrolysis. | |
| PubChem ID | NA | |
| Additional PMIDs | 33177555 27957760 18699780 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30011248-2 | |
| Safety | NA |