| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1851 | |
| Phytochemical name or plant extracts | Panepoxydone | |
| PMID | 25575825 | |
| Literature evidence | Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers. | |
| IUPAC name | (1S,5R,6S)-5-hydroxy-3-[(1R)-1-hydroxy-3-methylbut-2-enyl]-7-oxabicyclo[4.1.0]hept-3-en-2-one | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Penicillium griseum | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | LDH-B, LDH-A, NF-κB | |
| Gene or Protein evidence | PP also up-regulated LDH-B and down-regulated LDH-A expression levels in all breast cancer cells to similar levels observed in HMEC cells. Panepoxydone (PP), a natural NF-kB inhibitor. Furthermore, inhibitors of NF-kB could serve as a therapeutic agent for targeting metabolism and for the treatment of triple negative breast cancer. | |
| Target pathways | NA | |
| IC50 | 4 uM against MDA-MB-453 5uM against MCF-7 8uM against MDA-MB-468 15 uM against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231, MDA-MB-468, MDA-MB-453 | |
| Additional information | NA | |
| PubChem ID | 10130519 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |