| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-680 | |
| Phytochemical name or plant extracts | Pandanus amaryllifolius extract | |
| PMID | 22909149 | |
| Literature evidence | BACKGROUND: Our previous study had shown that P. amaryllifolius was able to selectively inhibit cell proliferation of hormone independent breast cancer cell line MDA-MB-231. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Pandanus amaryllifolius | |
| Geographical availability | Maluku | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 8, Caspase 9, Caspase 3, Caspase 7 | |
| Gene or Protein evidence | Increased relative concentration of initiator caspase 8 and 9 was also observed following exposure to P. amaryllifolius ethanol extract of MDA-MB-231 cells. Significant one fold increment (p < 0.05) in activity of effector caspase 3/7 was detected in MDA-MB-231 cells at 24 and at 48 hr, more than four fold increment of caspase 3/7 was noted when compared to control cells, following exposure to P. amaryllifolius ethanol extract | |
| Target pathways | NA | |
| IC50 | 90 μg/mL against MDA-MB-231 | |
| Potency | Our findings suggest that P. amaryllifolius ethanol extract induced apoptosis on hormone independent breast cancer cell line MDA-MB-231. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | ELISA for cytochrome c, caspase-3/7, 8 and 9 indicated that apoptosis was contributed by mitochondrial cytochrome c release via induction of caspase 3/7, 9, and p53 was associated with the suppression of XIAP in P. amaryllifolius treated MDA-MB-231 cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:670690-1 | |
| Safety | NA |