| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-675 | |
| Phytochemical name or plant extracts | Pancratium maritimum extract | |
| PMID | 30364050 | |
| Literature evidence | The most promising ABTS scavenging capacity was observed with fruits ethanol extract (ET1) that showed an IC50 value of 6.9 μg/mL. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic and Aqueous extract | |
| Source of phytochemicals or plant Extracts | Pancratium maritimum | |
| Geographical availability | Albania, Algeria, Baleares, Bulgaria, Canary Is., Corse, Cyprus, East Aegean Is., Egypt, France, Greece, Italy, Kriti, Lebanon-Syria, Libya, Morocco, North Caucasus, Palestine, Portugal, Sardegna, Sicilia, Sinai, Spain, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Yugoslavia | |
| Plant parts | Stem, Flowers, bulbs, and Fruits | |
| Other cancers | Breast cancer, Lung cancer, Cervical cancer, Prostate cancer | |
| Target gene or protein | Cyclin B1, Bcl-2, Ki67 | |
| Gene or Protein evidence | P. maritimum extract has anti-proliferative effects on MDA-MB-231 cell line in vitro. The effects imply the involvement of mechanisms that inhibits cell growth and arresting cells at S and G2/M phases. Cyclin B1, Bcl-2, and Ki67 expression was also affected. | |
| Target pathways | NA | |
| IC50 | Fruits aqueous extract (AQ) against MCF-7 cell line (IC50 of 36.5 μg/mL). The IC50 values were 0.039, 0.035, and 0.026 mg/ml after 48, 72, and 96 hours of treatment with 0.1 mg/ml concentration of bulb extract, respectively. | |
| Potency | According to the correlation results, the phenols and flavonoids content could provide a fundamental contribution to the antioxidant and antiproliferative activity of P. maritimum extracts. | |
| Cell line/ mice model | C32, HeLa, MDA-MB-231, PC3, A549, MCF-7, and LNCaP | |
| Additional information | Interesting results were obtained with stems ethanol extract (ET1) against C32 cells (IC50 of 27.1 μg/mL) and fruits aqueous extract (AQ) against MCF-7 cell line (IC50 of 36.5 μg/mL). | |
| PubChem ID | NA | |
| Additional PMIDs | 29398752 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:66466-1 | |
| Safety | NA |