| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-160 | |
| Phytochemical name or plant extracts | Pallenis spinosa essential oil | |
| PMID | 28803233 | |
| Literature evidence | BACKGROUND/AIMS: In our quest for new natural anticancer agents, we studied the cytotoxicity of the essential oils extracted from flowers and leaves of Pallines spinosa. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Essential oil | |
| Source of phytochemicals or plant Extracts | Pallenis spinosa | |
| Geographical availability | Albania, Algeria, Baleares, Bulgaria, Canary Is., Corse, Cyprus, East Aegean Is., Egypt, France, Greece, Iran, Iraq, Italy, Kriti, Lebanon-Syria, Libya, Morocco, North Caucasus, Palestine, Portugal, Sardegna, Sicilia, Spain, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Yugoslavia | |
| Plant parts | Leaves and Flowers | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2 , Bax , Cyclin D1, CDK4, p21 | |
| Gene or Protein evidence | Both oils induced a caspase-dependent and -independent apoptosis in MCF-7 and MDA-MB-231 cells, and altered the levels of Bcl-2 and Bax proteins. In addition, the oils arrested cell cycle in both cancer cell lines at G0/G1 phase by modulating the expression of cyclin D1, CDK4 and p21 proteins. | |
| Target pathways | NA | |
| IC50 | Flower oil - 0.25 ± 0.03 µg/mL against MCF-7 and 0.21 ± 0.03 µg/mL against MDA-MB-231 Leaf oil - 2.4 ± 0.5 µg/mL against MCF-7 and 1.5 ± 0.1 µg/mL against MDA-MB-231 | |
| Potency | The toxicity of the flower oil was ∼5 to 8-times less in normal MCF-10-2A (IC50 1.3 ± 0.2 µg/mL) and blood mononuclear cells (2.80 ± 0.45 µg/mL) as compared to breast and hematological cancer cells, respectively. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | The cytotoxicity of P. spinosa oils were mediated by apoptosis and cell cycle arrest, suggesting the potential use of their bioactive compounds as natural anticancer compounds. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:236401-1 | |
| Safety | NA |