| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-736 | |
| Phytochemical name or plant extracts | Paeoniflorin | |
| PMID | 27175085 | |
| Literature evidence | This finding provides evidence that PF can serve as a therapeutic agent for the treatment of breast cancer. | |
| IUPAC name | [(1R,2S,3R,5R,6R,8S)-6-hydroxy-8-methyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9,10-dioxatetracyclo[4.3.1.02,5.03,8]decan-2-yl]methyl benzoate | |
| Phytochemicals’ class or type of plant extracts | Monoterpene | |
| Source of phytochemicals or plant Extracts | Paeonia lactiflora | |
| Geographical availability | Amur, China North-Central, China South-Central, China Southeast, Chita, Inner Mongolia, Khabarovsk, Manchuria, Mongolia, Primorye | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | PI3K, AKT, HIF-1α, NOTCH‑1 and HES‑1 | |
| Gene or Protein evidence | Furthermore, PF prevented hypoxia-induced expression of phosphorylated PI3K and Akt in MDA-MB-231 cells. In conclusion, PF prevented hypoxia-induced EMT in breast cancer cells by inhibiting HIF-1α expression via modulation of PI3K/Akt signaling pathway. NOTCH‑1 and HES‑1 protein levels demonstrated a similar trend to the mRNA levels, whereby an increase in the concentration of PF was associated with a decrease in NOTCH‑1 and HES‑1 protein expression levels. | |
| Target pathways | PI3K/Akt signaling pathway, NOTCH‑1 signaling pathway | |
| IC50 | NA | |
| Potency | The results presented in this study demonstrate that PF blocks the migration and invasion of breast cancer cells by repressing EMT under hypoxic conditions. PF also significantly attenuated the hypoxia-induced increase in HIF-1α level. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | This finding provides evidence that PF can serve as a therapeutic agent for the treatment of breast cancer. | |
| PubChem ID | 442534 | |
| Additional PMIDs | 31858611 27175085 29115554 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:711802-1 | |
| Safety | NA |